September                   Back to the articles list | Back to browse issues page


XML Print


Abstract:   (77 Views)
Neural synchronization is considered as a key role in several neurological diseases, such as Parkinson’s and Epilepsy’s disease. During these diseases, there is increased synchronization of massive numbers of neurons. In addition, evidences show that astrocytes modulate the synaptic interactions of the neuronal population. The Astrocyte is an important part of a neural network that can be involved in the desynchronization of the neuronal population. In this paper, we design a new analog neuromorphic circuit to implement the effect of astrocyte in the desynchronization of neural networks. The simulation results demonstrate that the astrocyte circuit as a feedback path can be desynchronized to a synchronized neural population. In this circuit, as a first step, the population of twenty neurons is synchronized with the same input currents. Next, by involving an astrocyte feedback circuit, the synchronization of the neural network is disturbed. Then, the neuronal population will be desynchronized. The proposed circuit is designed and simulated using HSPICE simulator in 0.35 μm standard CMOS technology.
Full-Text [PDF 1279 kb]   (17 Downloads)    
  • Proposing a new analog neuromorphic circuit to implement the effect of astrocyte in desynchronization of the neural network;
  • Proposing a population of twenty neurons is synchronized with the same input currents;
  • By involving the astrocyte feedback circuit, the synchronization of the neural network is disturbed;
  • The proposed circuit is designed and simulated using HSPICE simulator in 0.35μm standard CMOS technology.

Type of Study: Research Paper | Subject: Biological Modelling & Simulation
Received: 2019/09/29 | Revised: 2020/12/09 | Accepted: 2020/12/24

Creative Commons License
© 2021 by the authors. Licensee IUST, Tehran, Iran. This is an open access journal distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license.